FITC Conjugated Anti-CD1b Monoclonal Antibody (Clone:SN13)
Figure 1: Separation of human CD1b positive dendritic cells differentiated upon monocyte stimulation (GM-CSF + IL-4) (red) from CD1b negative monocytes (blue) in flow cytometry analysis (surface staining) of human stimulated (GM-CSF + IL-4) peripheral blood mononuclear cells stained using anti-human CD1b (SN13) FITC antibody
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| Amount : | 100 tests |
| Isotype : | Mouse IgG1 |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
CD1b (also known as R1) together with CD1a and c, belongs to group 1 of CD1 antigens. These non-classical MHC-like glycoproteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. The trafficking routes of the particular CD1 types differ and correspond to their ability to bind and present different groups of antigens. Besides non-peptide glycolipid antigen presentation to CD1-restricted T cells, CD1b has been implicated in thymocyte development.
| Subcellular location: | Cell membrane, Endosome membrane, Lysosome membrane |
| Tissue Specificity: | Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues. |
| BioGrid: | 107348. 54 interactions. |
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