APC Conjugated Anti-CD300e / IREM-2 Monoclonal Antibody (Clone:UP-H2)
Figure 1: Surface staining of human peripheral blood with anti-human CD300e (UP-H2) APC.
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| Amount : | 100 tests |
| Isotype : | Mouse IgG1 |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
CD300e / IREM-2 (immune receptor expressed by myeloid cells 2), also known as CLM2 or LMIR6, is a monomeric transmembrane glycoprotein with a single extracellular immunoglobulin-like domain. Intracellularly it associates with DAP-12, an ITAM-containing adaptor molecule. CD300e is expressed on mature monocytes and peripheral blood myeloid dendritic cells. Its crosslinking leads to release of pro-inflammatory cytokines, and increased expression of activation markers.
| Subcellular location: | Cell membrane |
| Post transnational modification: | N-glycosylated. |
| Tissue Specificity: | Present on the surface of mature hematopoietic cells of the monocyte and myeloid lineages (at protein level). |
| BioGrid: | 131180. 8 interactions. |
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