Anti-STIM1 / GOK Monoclonal Antibody (Clone:CDN3H4)
Figure 1: Western Blotting analysis (non-reducing conditions) of whole cell lysate of RBL rat basophilic leukemia cell line.Lane 1: immunostaining with anti-STIM1 (CDN3H4)Lane 2: immunostaining with Isotype mouse IgG1 control (PPV-06; )
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Purification : | Purified by protein-A affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
STIM1 (stromal interacting molecule; also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet. Many questions also remain to be solved around STIM1 functional distribution. It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.
Immunoprecipitation Western Blotting Recommended dilution: 1 µg/ml
Positive control: RBL rat basophilic leukemia cell line
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane, Endoplasmic reticulum membrane, Cytoplasm, Sarcoplasmic reticulum |
| Post transnational modification: | Phosphorylated predominantly on Ser residues. |
| Tissue Specificity: | Ubiquitously expressed in various human primary cells and tumor cell lines. |
| BioGrid: | 112662. 31 interactions. |
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