Anti-Protein Tyrosine Phosphatase, non-receptor type 6 Monoclonal Antibody(Clone: CPTC-PTPN6-2)
Fig. 1: SDS-PAGE Analysis Purified PTPN6 Mouse Monoclonal Antibody (CPTC-PTPN6-2). Confirmation of Purity and Integrity of Antibody.
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Shipping Info:
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Amount : | 100 µg |
Isotype : | Mouse IgG2a, kappa |
Content : | 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
Storage condition : | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. |
Gene : | PTPN6 |
Gene ID : | 5777 |
Uniprot ID : | P29350 |
Alternative Name : | PTPN6; SHP1; protein tyrosine phosphatase, non-receptor type 6; HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; 70 kda SHP-1L protein; hematopoietic cell phosphatase; hematopoietic cell protein-tyrosine phosphatase; protein-tyrosine phosphatase 1C; PTPN6 / SHP |
Immunogen Information : | Recombinant human full-length PTPN6 protein |
PTPN6, which is also designated as SHP-1, is expressed primarily in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. It maps to 12p13, a region commonly involved in leukemia-associated chromosomal abnormalities. SHP-1 plays a role in modulating intracellular signaling for various molecules. In T-cell lymphomas and other malignancies, SHP-1 phosphatase expression is lost, by a thus far undetermined mechanism. Preliminary studies sµggest that it may be helpful in differentiating mantle/marginal zone lymphomas (SHP-1+) from follicular lymphomas (SHP-1 negative).
ELISA (For coating, purchase antibody without BSA); Western Blot (1-2ug/ml);
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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