Anti-NTAL / LAB Polyclonal Antibody(Discontinued)
Figure 1: Western Blotting analysis (non-reducing conditions) of NTAL-transfected HEK-293 FT cells using polyclonal anti-human NTAL antibody. Lane 1: cell lysate of transfected HEK-293 FT cells. Lane 2: cell lysate of non-transfected HEK-293 FT cells (negative control)
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Rabbit IgG |
| Purification : | Purified from rabbit serum by affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
NTAL (Non-T cell activation linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.
Western Blotting Recommended dilution: 1 µg/mlImmunohistochemistry
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane |
| Post transnational modification: | May be polyubiquitinated. |
| Tissue Specificity: | Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level). |
| BioGrid: | 113301. 4 interactions. |
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