Anti-MSH6 Monoclonal Antibody (Clone:IHC006)(Discontinued)

Product code: 44-1047

Clone name : IHC006
Clonality : Monoclonal
Application : IHC
Reactivity : Human

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Format : Purified
Amount : 0.5 ml
Isotype : Mouse IgG1
Purification : Protein A/G Chromatography
Content : Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
Storage condition : Store at 2°C - 8°C. Do not freeze.
Gene : MSH6
Gene ID : 2956
Uniprot ID : P52701
Alternative Name : MSH6, GTBP
Immunogen Information : Recombinant Human MSH6
MutS Homolog 6 (MSH6) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with the development of sporadic colorectal carcinoma. Studies have shown that mutations in MSH6, when co-indicated with mutations in MSH1 and MSH2, contribute to the development of sporadic colorectal carcinoma. Use of Anti-MSH6 is optimized when paired in an IHC panel with MSH2, MLH1, and PMS2.

Recommended dilutions: Immunohistochemical analysis: 1:100 - 1:200. However, this need to be optimized based on the research applications.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Nucleus, Chromosome
Post transnational modification: Phosphorylated by PRKCZ, which may prevent MutS alpha degradation by the ubiquitin-proteasome pathway.
BioGrid: 109211. 92 interactions.
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