FITC Conjugated Anti-IgE Monoclonal Antibody (Clone:BE5)
Figure 1: Flow Cytometry analysis of basophil activation upon stimulation of normal (heparin-treated) whole blood with combination of IL-3 and Goat anti-IgE polyclonal antibody.Combination of anti-human IgE (BE5) FITC and anti-human CD63 (MEM-259) PE-Dyomics 647) was used (analysis in basophil window). Fig. 1A - staining of non-stimulated (control) sampleFig. 1B - staining of IgE stimulated sample
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| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Content : | 0.1 mg/ml, Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
| Gene : | IGHE |
| Uniprot ID : | P01854 |
| Alternative Name : | Immunoglobulin heavy constant epsilon |
| Immunogen Information : | Purified human IgE. |
Immunoglobulin E (IgE) is a 180 kDa soluble protein serving as an antigen-specific unit of mast cell effector mechanisms. IgE has the lowest serum concentration of all immunoglobulins (approximately 0.5 mg/l) in healthy individuals, but upon allergen challenge its concentration in blood increases dramatically. Although biological survival of free IgE is very short (T1/2 = 2 days), it is stabilized after binding to its high affinity receptor. Unlike IgM- IgG- and IgA-committed B cells, IgE-switched B cells do not undergo clonal expansion.
Flow cytometry: Recommended dilution: 5 μg/ml.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Secreted, Cell membrane |
| Post transnational modification: | The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding. |
| BioGrid: | 108502. 4 interactions. |
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