Anti-Human SIGLEC10 Mab (Clone: 5G6 )

Product code: 30-2868

Clone name : 5G6
Clonality : Monoclonal
Application : IP, ELISA, IHC
Reactivity : Human
Conjugate : Unconjugated

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0.1 mg
$398.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography.
Content : 1 mg/ml Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage condition : Store at 2-8°C. Do not freeze.
Gene : SIGLEC10
Gene ID : 89790
Uniprot ID : Q96LC7
Alternative Name : PRO940, SGL2, sialic acid binding Ig like lectin 10
Immunogen Information : SIGLEC10 extracellular domain fused with human IgG1 Fc fragment

Specificity : The mouse monoclonal antibody 5G6 recognizes an extracellular epitope of human SIGLEC10, a sialic acid-binding lectin expressed on subsets of human leucocytes.

SIGLEC10 is a CD33-related receptor of sialoglycans, expressed on eosinophils, monocytes, a subpopulation of NK cells, and at lower level on B cells. Its murine ortholog is Siglec G. SIGLEC10 seems to act as an immunomodulatory receptor, which binds to VAP-1, a glycoprotein expressed on endothelium under inflammatory conditions. Another ligand of SIGLEC10 is CD24, a marker of poorer prognosis in carcinomas.

 

The mouse monoclonal antibody 5G6 recognizes an extracellular epitope of human SIGLEC10, a sialic acid-binding lectin expressed on subsets of human leucocytes.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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