Anti-HLA-E APC Mab (3D12)

Product code: 30-2912

Clone name : 3D12
Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : APC

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0.1 mg
$555.00 

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Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Content : Concentration: 0.1 mg/ml
Storage Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage condition : Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Gene : HLA-E
Gene ID : 3133
Uniprot ID : P13747
Alternative Name : HLA class I histocompatibility antigen, alpha chain E, MHC class I antigen E
Immunogen Information : Recombinant human HLA-E

Specificity: The mouse monoclonal antibody 3D12 (also known as 3D12HLA-E) recognizes native extracellular part of HLA-E, an ubiquitously expressed non-classical MHC class I molecule, as well as free HLA-E.

HLA-E (human leukocyte antigen E) is a non-classical MHC I antigen, which is important for dialogue with NK cells and their regulation through interaction with CD94/NKG2 receptor. Like other MHC I molecules, transmembrane HLA-E molecule (45 kDa) associates with beta2 microglobulin. Unlike HLA-G, expression of HLA-E molecules is not so restricted, but it has been detected at least at mRNA level in virtually all cells and tissues examined. In peripheral blood, HLA-E protein is expressed at least in all mononuclear cells, but in different quantity (B cells and monocytes more than T cells and NK cells).

 

Flow cytometry: Recommended dilution: 1-4 μg/ml.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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