Anti-CD68 Monoclonal Antibody (Clone:Y1/82A)-PE Conjugated

Product code: 30-2369

Clone name : Y1/82A
Clonality : Monoclonal
Application : FACS, IHC-Fr
Reactivity : Human
Conjugate : PE

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100 tests
$468.00 

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Amount : 100 tests
Isotype : Mouse IgG2b
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : CD68
Gene ID : 968
Uniprot ID : P34810
Alternative Name : CD68
Immunogen Information : Lysosomal contents of lung macrophages
CD68 (also known as LAMP4 or SCARD1) is a 110 kDa type I transmembrane glycoprotein of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family and the scavenger receptor family. Although CD68 primarily localizes to lysosomes and endosomes, its fraction circulates to the cell surface. By the heavily glycosylated extracellular domain CD68 binds to tissue- and organ-specific lectins or selectins. It is expressed mainly in cytoplasmic granules of monocytes/macrophages, granulocytes, and dendritic cells, but also e.g. in a proportion of epithelial tumours (diagnosis of poorly differentiated neoplasms).
Subcellular location: Endosome membrane, Lysosome membrane
Post transnational modification: N- and O-glycosylated.
Tissue Specificity: Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.
BioGrid: 107406. 15 interactions.
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