Anti-CD42b / GPIb alpha Monoclonal Antibody (Clone:HIP1)-PE Conjugated(Discontinued)

Product code: 30-2219

Clone name : HIP1
Clonality : Monoclonal
Application : FACS, IHC-Fr, Functional Assay
Reactivity : Human, Non-Human Primates
Conjugate : PE

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Amount : 100 tests
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : GP1BA
Gene ID : 2811
Uniprot ID : P07359
Alternative Name : GP1BA
Immunogen Information : Peripheral blood mononuclear cells of a patient suffering with CLL.
CD42b (GPIb alpha) composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.
Subcellular location: Membrane
Post transnational modification: Glycocalicin, which is approximately coextensive with the extracellular part of the molecule, is cleaved off by calpain during platelet lysis.
BioGrid: 109073. 10 interactions.
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