Anti-CD328 / Siglec-7 Monoclonal Antibody (Clone:6-434)-PE Conjugated

Product code: 30-2403

Clone name : 6-434
Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : PE

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100 tests
$468.00 

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Amount : 100 tests
Isotype : Mouse IgG1
Storage condition : Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Gene : SIGLEC7
Gene ID : 27036
Uniprot ID : Q9Y286
Alternative Name : SIGLEC7, AIRM1
Immunogen Information : human dendritic cells
CD328, also known as Siglec-7 or p75/AIRM1, is a 75 kDa type I transmembrane glycoprotein of sialic acid-binding immunoglobulin-like lectin (Siglec) family. CD328 binds to sialylated glycans with alpha2,6 sialyl and alpha2,8 disyalyl residues and mediates sialic acid-dependent cell-cell binding. As it contains in its intracellular part the immunoreceptor tyrosine-based inhibitory motif (ITIM), it serves as an inhibitory receptor, e.g. of NK cells.
Subcellular location: Membrane
Post transnational modification: Tyrosine phosphorylated.
Tissue Specificity: Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.
BioGrid: 117967. 7 interactions.
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