PE Conjugated, Anti-CD28 Monoclonal Antibody (Clone:CD28.2)
Figure 1: Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD28 (CD28.2) PE antibody (20 μl reagent / 100 μl of peripheral whole blood).
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| Amount : | 100 tests |
| Isotype : | Mouse IgG1 |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
CD28 is the critical T cell costimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its costimulation role CD28 functions in preventing T cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.
| Subcellular location: | Cell surface |
| Post transnational modification: | CD40LG induces tyrosine phosphorylation of isoform 3. |
| Tissue Specificity: | Expressed in T-cells and plasma cells, but not in less mature B-cells. |
| BioGrid: | 107378. 20 interactions. |
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