Anti-CD279 / PD-1 Monoclonal Antibody (Clone:EH12.2H7)-PE Conjugated
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Figure 1: Surface staining of PHA-activated (3 days) human PBMC with anti-CD279 (EH12.2H7) PE.
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Amount : | 100 tests |
Isotype : | Mouse IgG1 |
Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
CD279 / PD-1 (programmed cell death 1), a transmembrane protein of CD28/CTLA-4 family. It is expressed inducibly mainly on activated T, B, and myeloid cells and plays a role in maintaining peripheral self-tolerance. Binding to its receptors CD273 and CD274 is associated with inhibition of T cell proliferation and induction of their anergy. It is also expressed during thymic development. Some variants of CD279 are associated with susceptibility to systemic lupus erythematosus, type 1 diabetes, and rheumatoid arthritis.
Subcellular location: | Membrane |
BioGrid: | 111160. 61 interactions. |
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