Anti-CD23 Monoclonal Antibody (Clone:EBVCS-5)-FITC Conjugated(Discontinued)
Figure 1: Surface staining of human peripheral blood cells with anti-human CD23 (EBVCS-5) FITC.
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| Amount : | 100 tests |
| Isotype : | Mouse IgG1 |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
CD23 (Fc epsilon RII), the low affinity IgE receptor, is a 45 kDa type II membrane glycoprotein expressed more or less on eosinophils, follicular dendritic cells, Langerhans cells, mature B cells (mainly upon activation), EBV-transformed lymphoblasts, monocytes, and subpopulation of platelets. A soluble form of 37 kDa and other its fragments were also described. CD23 mediates IgE-dependent cytotoxicity by eosinophils and macrophages, and downregulates IgE secretion in response to high levels of IgE, involving release of pro-inflammatory cytokines.
| Subcellular location: | Cell membrane, Cell membrane, Secreted |
| Post transnational modification: | The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding. |
| BioGrid: | 108502. 4 interactions. |
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