Anti-CD222 / IGF2 receptor / CIMPR Monoclonal Antibody (Clone:MEM-238)

Product code: 30-1200

Clone name : MEM-238
Clonality : Monoclonal
Application : FACS, IP, WB
Reactivity : Human, Non-Human Primates

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0.1 mg
$407.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : IGF2R
Gene ID : 3482
Uniprot ID : P11717
Alternative Name : IGF2R, MPRI
Immunogen Information : Recombinant Vaccinia virus encoding CD222.
CD222 (CIMPR, cation-independent mannose 6-phosphate receptor; IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10% of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-beta, last but not least CD222 serves as a receptor for heparanase and even for Listeria.
Subcellular location: Lysosome membrane
BioGrid: 109703. 40 interactions.
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