Anti-CD14 / LPS-receptor Monoclonal Antibody (Clone:MEM-15)
Figure 1: Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD14 (MEM-15) purified antibody
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Purification : | Purified by protein-A affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
CD14 is a 55 kDa GPI-anchored glycoprotein, constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils, where serves as a multifunctional lipopolysaccharide receptor; it is also released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 is able to discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. CD14 affects allergic, inflammatory and infectious processes.
Flow Cytometry Recommended dilution:4 µg/ml
Immunoprecipitation excellent for immunoprecipitation of CD14
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell membrane, Secreted, Membrane raft, Golgi apparatus |
| Post transnational modification: | N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan. |
| Tissue Specificity: | Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages. |
| BioGrid: | 107367. 35 interactions. |
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