TLR2/HEK293 Stable Cell Line
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Fig-1: Functional analysis of the TLR2/HEK293 cell line. TLR2/HEK293 cells as well as parental HEK293 cells were transfected with NF-kB/Renilla luciferase reporter plasmid for 16 h. Cells were stimulated with different doses of Pam3CSK4 (Abeomics, Cat. #15-1011) for 16 h followed by luciferase assay using Luciferase Assay Reagent (Abeomics, Cat. #17-1101).
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Shipping Info:
Order now and get it on Tuesday September 03, 2024
Same day delivery FREE on San Diego area orders placed by 1.00 PM
Amount : | 1 Vial |
Content : | Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO |
Storage condition : | Immediately upon receipt, store in liquid nitrogen. |
TLR2/HEK293 Stable Cell Line is a stably transfected HEK293 cell line which expresses human Toll-like receptor 2 (TLR2, also designated as CD282). TLR2 mediates immune responses by recognition of lipid-containing pathogen-associated molecular patterns (PAMPs) such as lipoteichoic acid and di- and tri-acylated cysteine-containing lipoproteins. TLR2 forms heterodimers with TLR1 or TLR6 as the initial step in a signal transduction cascade which leads to significant innate immune responses as well as development of adaptive immunity. TLR2-TLR1 heterodimers recognize triacylated lipopeptides from Gram-negative bacteria and mycoplasma, while TLR2-TLR6 heterodimers recognize diacylated lipopeptides from Gram-positive bacteria and mycoplasma. Note that TLR2 in the TLR2/HEK293 stable cell line contains the N-terminal HA tag (Figure 2), which does not interfere with TLR2 activity as confirmed by functional assay (Figure 1).
Sequence data: Human TLR2 (accession number NP_001305716)
Application:.
- Functional assay.
Culture conditions:
LIMITED USE RESTRICTIONS:
THIS PRODUCT IS SOLELY FOR IN VITRO RESEARCH USE ONLY. NOT FOR DIAGNOSTIC OR THERAPEUTIC USE.
By use of this product, user agrees to be bound by the terms of this limited use statement.
This product is solely for Internal Research Purposes and not for Commercial Purposes. Commercial Purposes include, but are not limited to (1) use of the cell line in manufacturing; (2) use of the cell line to provide a service, information or data; (3) use of the cell line for therapeutic, diagnostic or prophylactic purposes; or (4) resale of the cell line whether or not such cell lines are resold for use in research. The buyer cannot sell, give or otherwise transfer this product to a third party.
Commercial License Agreement is available for non-research use if applicable. Please contact Abeomics ([email protected]).
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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