Recombinant Rat TNF-Alpha(Discontinued)

Product code: 32-20240

Reactivity : Human, Monkey, Mouse, Rat

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Amount : 20 µg
Purification : Purity: >= 98% by SDS-PAGE gel and HPLC analyses.
AA sequence : MLRSSSQNSS DKPVAHVVAN HQAEEQLEWL SQRANALLAN GMDLKDNQLV VPADGLYLIY SQVLFKGQGC PDYVLLTHTV SRFAISYQEK VSLLSAIKSP CPKDTPEGAE LKPWYEPMYL GGVFQLEKGD LLSAEVNLPK YLDITESGQV YFGVIAL
Alternative Name : Tumor Necrosis Factor, TNFSF2, Cachectin, Differentiation-inducing factor (DIF), Necrosin, Cytotoxin
Source:E.coli
TNF-Alpha is a pleiotropic pro-inflammatory cytokine secreted by various cells, including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands, and signals through two receptors, TNFR1 and TNFR2. TNF-Alpha is cytotoxic to a wide variety of tumor cells, and is an essential factor in mediating the immune response against bacterial infections. TNF-Alpha also plays a role in the induction of septic shock, autoimmune diseases, rheumatoid arthritis, inflammation, and diabetes. Human and murine TNF-Alpha demonstrate significant cross-species reactivity. TNF-Alpha exists in two forms; a type II transmembrane protein, and a mature soluble protein. The TNF-Alpha transmembrane protein is proteolytically cleaved to yield a soluble, biologically active, 17 kDa TNF-Alpha, which forms a non-covalently linked homotrimer in solution. Recombinant Rat TNF-Alpha is a soluble 157 amino acid protein (17.3 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.

The ED50 as determined by the cytolysis of murine L929 cells in the presence of actinomycin D is <= 0.05 ng/ml, corresponding to a specific activity of >= 2 x 107 units/mg.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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