Recombinant Rat IL-13 (109 a.a.)(Discontinued)
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| Amount : | 10 µg |
| Purification : | Purity: >= 98% by SDS-PAGE gel and HPLC analyses. |
| Content : | This recombinant protein is supplied in lyophilized form. |
| AA sequence : | VRRSTSPPVA LRELIEELSN ITQDQKTSLC NSSIVWSVDI TAGGFCAALE SLTNISSCNA IHRTQRILNG LCNQKASDVA SSPPDTKIEV AQFISKLLNY SKQLFRYGH |
| Alternative Name : | NC300 (Human), P600 (Murine) |
Source:E.coliIL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1Beta, TNF-Alpha, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching, resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 are cross-species reactive. Recombinant Rat IL-13 is an 11.9 kDa protein consisting of 109 amino acid residues.
The ED50 as determined by the dose-dependant stimulation of the proliferation of human TF-1 cells is < 40 ng/ml, corresponding to a specific activity of > 2.5 x 104 units/mg.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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