Recombinant Rat IFN-Gamma(Discontinued)
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| Amount : | 100 µg |
| Purification : | Purity: >= 98% by SDS-PAGE gel and HPLC analyses. |
| Content : | This recombinant protein is supplied in lyophilized form. |
| AA sequence : | MQGTLIESLE SLKNYFNSSS MDAMEGKSLL LDIWRNWQKD GNTKILESQI ISFYLRLFEV LKDNQAISNN ISVIESHLIT NFFSNSKAKK DAFMSIAKFE VNNPQIQHKA VNELIRVIHQ LSPESSLRKR KRSRC |
| Alternative Name : | Immune Interferon, type II interferon, T cell interferon, MAF |
Source:E.coliIFN-Gamma is an acid-labile interferon produced by CD4 and CD8 T lymphocytes, as well as activated NK cells. IFN-Gamma receptors are present in most immune cells, which respond to IFN-Gamma signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-Gamma signaling in antigen-presenting cells, and antigen-recognizing B and T lymphocytes, regulates the antigen-specific phases of the immune response. Additionally, IFN-Gamma stimulates a number of lymphoid cell functions, including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-Gamma is species-specific and is biologically active only in human and primate cells. Recombinant Rat IFN-Gamma is a 15.6 kDa protein containing 135 amino acid residues.
The ED50 as determined by a cytopathic affect inhibition assay with murine L929 cells challenged with EMC virus was <= 0.1 ng/ml, corresponding to a specific activity of >= 1 x 107units/mg.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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