Recombinant Rabbit Monoclonal Antibody to Aurora-B (AURKB) (Clone: RM278)(Discontinued)
Figure 1: Western Blot of HeLa cells nontreated (-) or treated (+) with Nocodazole (NOC), using Anti-Aurora B Rabbit Monoclonal Antibody (Clone: RM278) at a 1:1000 dilution.
Roll over image to zoom in
Shipping Info:
For estimated delivery dates, please contact us at [email protected]
| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Rabbit IgG |
| Purification : | Protein A affinity purified from an animal origin-free culture supernatant |
| Content : | Antibody in 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide |
| Storage condition : | Store at -20°C. Avoid repeated freeze and thaw cycles. |
Clone RM278 reacts to human Aurora kinase B. Immunohistochemistry (IHC): 1:200-1:500 dilution; Western Blot (WB): 1:1000-1:2000 dilution.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Chromosome, Chromosome, Cytoplasm, Midbody |
| Post transnational modification: | Ubiquitinated by different BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complexes. Ubiquitinated by the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, ubiquitination leads to removal from mitotic chromosomes and is required for cytokinesis. During anaphase, the BCR(KLHL21) E3 ubiquitin ligase complex recruits the CPC complex from chromosomes to the spindle midzone and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome. |
| Tissue Specificity: | High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase. |
| BioGrid: | 114646. 170 interactions. |
|
There are currently no product reviews
|
.png "ACE2/HEK293 Stable Cell Line")
