Recombinant Murine IL-22(Discontinued)

Product code: 32-20453

Reactivity : Human, Mouse

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Amount : 10 µg
Purification : Purity:>= 98% by SDS-PAGE gel and HPLC analyses.
Content : This recombinant protein is supplied in lyophilized form.  
AA sequence : MLPVNTRCKL EVSNFQQPYI VNRTFMLAKE ASLADNNTDV RLIGEKLFRG VSAKDQCYLM KQVLNFTLED VLLPQSDRFQ PYMQEVVPFL TKLSNQLSSC HISGDDQNIQ KNVRRLKETV KKLGESGEIK AIGELDLLFM SLRNACV
Alternative Name : Interleukin-22, IL-TIF, Cytokine ZCYTO18
Source:E.coli
IL-22 is a member of the IL-10 family of regulatory cytokines, which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26.  Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions.  Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas.  IL-22 signals through a receptor system consisting of IL-10RBeta /CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family.  Recombinant Murine IL-22 is a 33.4 kDa, non-disulfide-linked, homodimeric protein consisting of two 147 amino acid polypeptide chains.

Determined by its ability to induce STAT3 activation in COLO 205 cells. The expected ED50 for this effect is 150-400 pg/ml.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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