Recombinant Murine Beta -NGF(Discontinued)
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Amount : | 20 µg |
Purification : | Purity:>= 98% by SDS-PAGE gel and HPLC analyses. |
Content : | This recombinant protein is supplied in lyophilized form. |
AA sequence : | SSTHPVFHMG EFSVCDSVSV WVGDKTTATD IKGKEVTVLA EVNINNSVFR QYFFETKCRA SNPVESGCRG IDSKHWNSYC TTTHTFVKAL TTDEKQAAWR FIRIDTACVC VLSRKATRRG |
Alternative Name : | NGF-Beta , beta-Nerve Growth Factor |
Source:E.coliBeta -NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Beta -NGF is a potent neurotrophic factor that signals through its receptor Beta -NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. Beta -NGF also acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival.  The functional form of Recombinant Murine Beta -NGF is a non-covalently-linked homodimer of two 13.4 kDa, polypeptide monomers that each contain 120 amino acids and three disulfide bonds, which are required for biological activity.
The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is <=1.0 ng/ml, corresponding to a specific activity of>= 1 x 106 units/mg.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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