Recombinant Mouse TREM-1 (C-His)

Product code: 32-9147

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  •   500 µg

  •  50 µg

  • $1,690.00 

  • $565.00 

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Amount : 50 µg
Content : Lyophilized from a 0.2 um filtered solution of PBS, pH7.4
AA sequence : Recombinant Mouse Triggering Receptor Expressed On Myeloid Cells 1 is produced by our Mammalian expression system and the target gene encoding Ala21-Ser202 is expressed with a 6His tag at the C-terminus.
Alternative Name : Triggering receptor expressed on myeloid cells 1; TREM-1; CD354; Trem1
Source : Human 293 Cells;
Triggering Receptor Expressed on Myeloid Cells 1, known as TREM-1, is a transmembrane protein with a single Ig-like domain. TREM-1 is expressed on blood neutrophils and monocytes, and the expression is up-regulated by bacterial LPS. TREM-1 is expressed at high levels on neutrophils of patients with microbial sepsis and in mice with a TREM-1/Fc fusion protein protected mice against LPS-induced shock. TREM-1 associates with the adapter protein, DAP12, to deliver an activating signal, which stimulates neutrophil and monocyte-mediated inflammatory responses. TREM-1 also triggers the release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. TREM-1 is an amplifier of inflammatory responses that are triggered by bacterial and fungal infections and are a crucial mediator of septic shock.
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