Recombinant Human ZW10 Interactor/ZWINT (N-His)
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| Amount : | 50 µg |
| Content : | Lyophilized from a 0.2 um filtered solution of 2umM PB, 15umM NaCl, pH 7.2 |
| AA sequence : | Recombinant Human ZWINT is produced by E. coli. The target gene encoding M1-P277 is expressed with a 6His tag at the N terminus. |
| Alternative Name : | ZW10 Interactor; ZW10-Interacting Protein 1; ZwintÂ1; ZWINT |
Source : E. coli;
ZW10 Interactor is localized to the kinetochores from late Prophase to Anaphase and has a uniform distribution in the cytoplasm of Interphase cells. ZWINT interacts ZW10, MIS12 and NDC80 subunit of the NDC80 complex specifically during mitosis. ZWINT is a part of the MIS12 complex which is required for kinetochore formation and spindle checkpoint activity. In addition, ZWINT is required to target ZW10 to the kinetochore at prometaphase.
ZW10 Interactor is localized to the kinetochores from late Prophase to Anaphase and has a uniform distribution in the cytoplasm of Interphase cells. ZWINT interacts ZW10, MIS12 and NDC80 subunit of the NDC80 complex specifically during mitosis. ZWINT is a part of the MIS12 complex which is required for kinetochore formation and spindle checkpoint activity. In addition, ZWINT is required to target ZW10 to the kinetochore at prometaphase.
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