Recombinant Human Vav 1 Guanine Nucleotide Exchange Factor
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| Amount : | 10 µg |
| Purification : | "Greater than 85% as determined by SDS-PAGE." |
| Content : | VAV1 protein solution (0.25mg/ml) containing In 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 30% glycerol and 2mM DTT. |
| Storage condition : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| AA sequence : | MGSSHHHHHH SSGLVPRGSH MGSMTEYDKR CCCLREIQQT EEKYTDTLGS IQQHFLKPLQ RFLKPQDIEI IFINIEDLLR VHTHFLKEMK EALGTPGAAN LYQVFIKYKE RFLVYGRYCS QVESASKHLD RVAAAREDVQ MKLEECSQRA NNGRFTLRDL LMVPMQRVLK YHLLLQELVK HTQEAMEKEN LRLALDAMRD LAQCVNEVKR DNETLRQITN FQLSIENLDQ SLAHYGRPKI DGELKITSVE RRSKMDRYAF LLDKALLICK RRGDSYDLKD FVNLHSFQVR DDSSGDRDNK KWSHMFLLIE DQGAQGYELF FKTRELKKKW MEQFEMAISN IYPENATANG HDFQMFSFEE TTSCKACQML LRGTFYQGYR CHRCRASAHK ECLGRVPPCG |
| Alternative Name : | Vav 1 Guanine Nucleotide Exchange Factor, VAV, Vav 1 Oncogene, Proto-Oncogene Vav. |
Source : Escherichia Coli.
VAV1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 400 amino acids (189-565a.a) and having a molecular mass of 46.8kDa.VAV1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Vav
1 Guanine Nucleotide Exchange Factor (VAV1), belongs to the VAV gene family.
The VAV1 proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases which
activate pathways leading to actin cytoskeletal rearrangements and transcriptional
alterations. VAV1 is essential in hematopoiesis, taking part in T-cell and
B-cell development and activation. VAV1 has been identified as the specific
binding partner of Nef proteins from HIV-1. In addition, VAV1 contains an SH2
domain, which could show its function as a substrate for tyrosine kinases. Expression
of VAV1 is limited solely to cells of hematopoietic origin, as well as those of
the erythroid, lymphoid and myeloid lineages. Among the diseases associated
with VAV1 are cherubism, and hiv-1.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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