Recombinant Human TWEAK Receptor(Discontinued)
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| Amount : | 25 µg |
| Purification : | Purity:>= 98% by SDS-PAGE gel and HPLC analyses. |
| Content : | This recombinant protein is supplied in lyophilized form. |
| AA sequence : | EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP |
| Alternative Name : | TNF-related weak inducer of apoptosis receptor, TNFRSF12A, FGF-inducible14, FN14 |
Source:E.coliTWEAKR belongs to the TNF family of transmembrane proteins, and contains a cytoplasmic "death domain", which can activate a cell's apoptotic machinery. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Signal transduction by TWEAKR can be activated by either membrane-anchored or soluble TWEAK. Recombinant Human soluble TWEAKR is a 53 amino acid polypeptide (5.6 kDa) comprising the entire extracellular domain of the full-length TWEAKR protein.
Determined by its ability to inhibit TWEAK-induced weak cell death of HT29 cells. The expected ED50for this effect is 1.0-3.0 µg/ml.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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