Recombinant Human TNF-Beta(Discontinued)

Product code: 32-20241

Reactivity : Human, Mouse

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Amount : 20 µg
Purification : Purity: >= 98% by SDS-PAGE gel and HPLC analyses.
AA sequence : MLPGVGLTPS AAQTARQHPK MHLAHSTLKP AAHLIGDPSK QNSLLWRANT DRAFLQDGFS LSNNSLLVPT SGIYFVYSQV VFSGKAYSPK ATSSPLYLAH EVQLFSSQYP FHVPLLSSQK MVYPGLQEPW LHSMYHGAAF QLTQGDQLST HTDGIPHLVL SPSTVFFGAF AL
Alternative Name : Tumor Necrosis Factor-Beta, TNFSF1B, Lymphotoxin-alpha (LT-Alpha)
Source:E.coli
TNF-Beta is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands, and signals through TNFR1 and TNFR2. TNF-Beta is produced by activated T and B lymphocytes, and has similar activities to TNF-Alpha. Like TNF-Alpha, TNF-Beta is involved in the regulation of various biological processes, including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-Beta is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-Beta, which effectively anchors the TNF-Beta to the cell surface. TNF-Beta is cytotoxic to a wide range of tumor cells. Recombinant Human TNF-Beta is a secreted 172 amino acid protein (18.6 kDa) which forms an active non-disulfide-linked homotrimer structure in solution.

The ED50 as determined by the cytolysis of murine L929 cells in the presence of Actinomycin-D is <= 0.05 ng/ml, corresponding to a specific activity of >= 2 x 107 units/mg.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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