Recombinant Human TNF-Alpha(Discontinued)
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| Amount : | 50 µg |
| Purification : | Purity: >= 98% by SDS-PAGE gel and HPLC analyses. |
| AA sequence : | VRSSSRTPSD KPVAHVVANP QAEGQLQWLN RRANALLANG VELRDNQLVV PSEGLYLIYS QVLFKGQGCP STHVLLTHTI SRIAVSYQTK VNLLSAIKSP CQRETPEGAE AKPWYEPIYL GGVFQLEKGD RLSAEINRPD YLDFAESGQV YFGIIAL |
| Alternative Name : | Tumor Necrosis Factor, TNFSF2, Cachectin, Differentiation-inducing factor (DIF), Necrosin, Cytotoxin |
Source:E.coli
TNF-Alpha is a pleiotropic pro-inflammatory cytokine secreted by various cells, including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands, and signals through two receptors, TNFR1 and TNFR2. TNF-Alpha is cytotoxic to a wide variety of tumor cells, and is an essential factor in mediating the immune response against bacterial infections. TNF-Alpha also plays a role in the induction of septic shock, autoimmune diseases, rheumatoid arthritis, inflammation, and diabetes. Human and murine TNF-Alpha demonstrate significant cross-species reactivity. TNF-Alpha exists in two forms; a type II transmembrane protein, and a mature soluble protein. The TNF-Alpha transmembrane protein is proteolitically cleaved to yield a soluble, biologically active, 17 kDa TNF-Alpha, which forms a non-covalently linked homotrimer in solution. Recombinant Human TNF-Alpha is a soluble 157 amino acid protein (17.4 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.
TNF-Alpha is a pleiotropic pro-inflammatory cytokine secreted by various cells, including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands, and signals through two receptors, TNFR1 and TNFR2. TNF-Alpha is cytotoxic to a wide variety of tumor cells, and is an essential factor in mediating the immune response against bacterial infections. TNF-Alpha also plays a role in the induction of septic shock, autoimmune diseases, rheumatoid arthritis, inflammation, and diabetes. Human and murine TNF-Alpha demonstrate significant cross-species reactivity. TNF-Alpha exists in two forms; a type II transmembrane protein, and a mature soluble protein. The TNF-Alpha transmembrane protein is proteolitically cleaved to yield a soluble, biologically active, 17 kDa TNF-Alpha, which forms a non-covalently linked homotrimer in solution. Recombinant Human TNF-Alpha is a soluble 157 amino acid protein (17.4 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.
The ED50 as determined by the cytolysis of murine L929 cells in the presence of Actinomycin D is <= 0.05 ng/ml, corresponding to a specific activity of >= 2 x 107 units/mg.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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