Recombinant Human TGF-Alpha (Discontinued)
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| Amount : | 100 µg |
| Purification : | Purity:>= 98% by SDS-PAGE gel and HPLC analyses. |
| Content : | This recombinant protein is supplied in lyophilized form. |
| AA sequence : | VVSHFNDCPD SHTQFCFHGT CRFLVQEDKP ACVCHSGYVG ARCEHADLLA |
| Alternative Name : | Transforming Growth Factor-Alpha , Sacroma growth factor, TGF-type I, ETGF |
Source:E.coliTGF-Alpha is an EGF-related polypeptide growth factor that signals through the EGF receptor, and stimulates the proliferation of a wide range of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and various tumor cells. TGF-Alpha induces anchorage-independence transformation in cultured cells. Human, murine and rat TGF-Alpha are cross-species reactive. Recombinant human TGF-Alpha is a 50 amino acid polypeptide (5.5 kDa) which shares approximately 40% sequence homology with EGF, including 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds.
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells is <=0.2 ng/ml, corresponding to a specific activity of>= 5 x 106 units/mg.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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