Recombinant Human Suppressor Of IKBKE 1
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| Amount : | 10 µg |
| Purification : | "Greater than 85% as determined by SDS-PAGE." |
| Content : | SIKE1 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 30% glycerol and 1mM DTT. |
| Storage condition : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| AA sequence : | MGSSHHHHHH SSGLVPRGSH MGSMSCTIEK ILTDAKTLLE RLREHDAAAE SLVDQSAALH RRVAAMREAG TALPDQYQED ASDMKDMSKY KPHILLSQEN TQIRDLQQEN RELWISLEEH QDALELIMSK YRKQMLQLMV AKKAVDAEPV LKAHQSHSAE IESQIDRICE MGEVMRKAVQ VDDDQFCKIQ EKLAQLELEN KELRELLSIS SESLQARKEN SMDTASQAIK |
| Alternative Name : | Suppressor Of IKBKE 1, SIKE, Suppressor Of IKK Epsilon, Suppressor Of IKK-Epsilon. |
Source : Escherichia Coli.
SIKE1 Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 230 amino acids (1-207 a.a) and
having a molecular mass of 26.1kDa.SIKE1 is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Suppressor of
IKBKE 1 also known as SIKE1 belongs to the SIKE family. SIKE interacts with
IKK-epsilon and TBK1 and function as a suppressor of TLR3 and virus-triggered
interferon activation pathways.
In addition, SIKE1 perform by disrupting the interactions of IKBKE or TBK1 with
TICAM1/TRIF, IRF3 andDDX58/RIG-I. SIKE1 does not inhibit NF-kappa-B activation
pathways.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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