Recombinant Human sTNF Receptor Type II(Discontinued)
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| Amount : | 20 µg |
| Purification : | Purity:>= 98% by SDS-PAGE gel and HPLC analyses. |
| Content : | This recombinant protein is supplied in lyophilized form. |
| AA sequence : | MAPEPGSTCR LREYYDQTAQ MCCSKCSPGQ HAKVFCTKTS DTVCDSCEDS TYTQLWNWVP ECLSCGSRCS SDQVETQACT REQNRICTCR PGWYCALSKQ EGCRLCAPLR KCRPGFGVAR PGTETSDVVC KPCAPGTFSN TTSSTDICRP HQICNVVAIP GNASMDAVCT STSP |
| Alternative Name : | soluble Tumor Necrosis Factor Type II, TNFRSF1B, TNFR75, p75, CD120b, TNFR80, p80, TNFR2 |
Source:E.coliTNFRII is a member of the TNFR family of transmembrane proteins, and is expressed in immune cells and certain endothelial cells. It is a high affinity receptor for TNF-Alpha , but manifests a lower affinity to TNF-Beta . Signaling through this receptor regulates various biological processes, including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. Soluble TNFRII is capable of inhibiting TNF-Alpha -induced activities by acting as a decoy receptor. The human TNFRII gene encodes for a 461 amino acid type I transmembrane protein, which contains a 22 amino acid signal sequence, a 235 amino acid extracellular domain, a 30 amino acid transmembrane domain, and a 174 amino acid cytoplasmic domain. Recombinant Human sTNF Receptor Type II is an 18.9 kDa protein (174 amino acid residues) comprising the cysteine-rich, ligand binding portion of the extracellular domain of the TNFRII protein.
Determined by its inhibitory effect of the TNF-Alpha mediated cytotoxicity in murine L-929 cells. The ED50for this effect in the presence of 0.25 ng/ml of Recombinant Human TNF-Alpha , is 0.125 µg/ml.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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