Recombinant Human SRSF Protein Kinase 2/SRPK2/SFRSK2 (C-6His)(Discontinued)
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| Amount : | 50 µg |
| Content : | Lyophilized from a 0.2 µm filtered solution of 20mM PB,150mM NaCl,pH7.4. |
| Storage condition : | Lyophilized protein should be stored at -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at -20°C for 3 months. |
| AA sequence : | MSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDRSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWGLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNSVDHHHHHH |
Source: Human Cells.
MW :78.5kD.
Recombinant Human SRSF Protein Kinase 2 is produced by our Mammalian expression system and the target gene encoding Met1-Ser688 is expressed with a 6His tag at the C-terminus. SRSF Protein Kinase 2 (SRPK2) belongs to the protein kinase superfamily and CMGC Ser/Thr protein kinase family. Serine/arginine-rich protein-specific kinase that specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. SFRSK2 can be cleaved into SRSF protein kinase 2 N-terminal and SRSF protein kinase 2 C-terminal chains and contains one protein kinase domain. SFRSK2 can mediate hepatitis B virus (HBV) core protein phosphorylation. SFRSK2 plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein.
MW :78.5kD.
Recombinant Human SRSF Protein Kinase 2 is produced by our Mammalian expression system and the target gene encoding Met1-Ser688 is expressed with a 6His tag at the C-terminus. SRSF Protein Kinase 2 (SRPK2) belongs to the protein kinase superfamily and CMGC Ser/Thr protein kinase family. Serine/arginine-rich protein-specific kinase that specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. SFRSK2 can be cleaved into SRSF protein kinase 2 N-terminal and SRSF protein kinase 2 C-terminal chains and contains one protein kinase domain. SFRSK2 can mediate hepatitis B virus (HBV) core protein phosphorylation. SFRSK2 plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein.
Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Endotoxin : Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cytoplasm, Nucleus |
| Post transnational modification: | Proteolytically cleaved at Asp-139 and Asp-403 by caspase-3 during apoptotic cell death. Cleavage at Asp-139 which is the major site of cleavage, produces a small N-terminal fragment that translocates into nucleus and promotes VP16-induced apoptosis. |
| Tissue Specificity: | Highly expressed in brain, moderately expressed in heart and skeletal muscle and at low levels in lung, liver, and kidney. |
| BioGrid: | 112611. 451 interactions. |
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