Recombinant Human Siglec-3/CD33 (C-hFc&His)
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| Amount : | 50 µg |
| Content : | Lyophilized from a 0.2 um filtered solution of PBS, 5% Trehalose, 0.01%Tween 80, pH7.2 |
| AA sequence : | Recombinant Human Sialic Acid Binding Ig-like Lectin 3 is produced by our Mammalian expression system and the target gene encoding Asp18-His259 is expressed with a Fc & 6His tag at the C-terminus. |
| Alternative Name : | Myeloid Cell Surface Antigen CD33; Sialic Acid-Binding Ig-Like Lectin 3; Siglec-3; gp67; CD33; SIGLEC3 |
Source : Human 293 Cells;
Myeloid cell surface antigen CD33 is a single-pass type I membrane protein that belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD33 is a putative adhesion molecule of myelomonocytic-derived cells that regulates sialic-acid dependent binding to cells. In the immune response, may act as an inhibitory receptor upon ligand-induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 induces apoptosis in acute myeloid leukemia.
Myeloid cell surface antigen CD33 is a single-pass type I membrane protein that belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD33 is a putative adhesion molecule of myelomonocytic-derived cells that regulates sialic-acid dependent binding to cells. In the immune response, may act as an inhibitory receptor upon ligand-induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 induces apoptosis in acute myeloid leukemia.
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