Recombinant Human Protein Down-Regulator of Transcription 1/DR1/NC2- beta (C-6His)(Discontinued)
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| Amount : | 50 µg |
| Content : | Lyophilized from a 0.2 µm filtered solution of 20mM TrisHCl, 150mM NaCl, 1mM DTT, pH 8.0. |
| Storage condition : | Lyophilized protein should be stored at -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at -20°C for 3 months. |
| AA sequence : | ASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCTEFIHLISSEANEICNKSEKKTISPEHVIQALESLGFGSYISEVKEVLQECKTVALKRRKASSRLENLGIPEEELLRQQQELFAKARQQQAELAQQEWLQMQQAAQQAQLAAASASASNQAGSSQDEEDDDDIVEHHHHHH |
Source: E.coli.
MW :20.5kD.
Recombinant Human NC2-beta is produced by our E.coli expression system and the target gene encoding Ala2-Ile176 is expressed with a 6His tag at the C-terminus. Protein Dr1 (DR1) belongs to the NC2 beta/DR1 family. DR1 contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. DR1 as a TBP associated phosphoprotein that represses both basal and activated levles of transcription. DR1 is an component of the ADA2A-containing complex (ATAC) which posses histone acetyltransferase activity on histone H3 and H4.
MW :20.5kD.
Recombinant Human NC2-beta is produced by our E.coli expression system and the target gene encoding Ala2-Ile176 is expressed with a 6His tag at the C-terminus. Protein Dr1 (DR1) belongs to the NC2 beta/DR1 family. DR1 contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. DR1 as a TBP associated phosphoprotein that represses both basal and activated levles of transcription. DR1 is an component of the ADA2A-containing complex (ATAC) which posses histone acetyltransferase activity on histone H3 and H4.
Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Endotoxin : Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus |
| Post transnational modification: | Phosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1. |
| BioGrid: | 108144. 45 interactions. |
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