Recombinant Human PRNP Protein, hFc Tag

Product code: 32-17858

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Available Pack Size(s)

  •   100 µg

  •   50 µg

  • $649.00 

  • $527.00 

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Amount : 50 µg
Content : Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.
Storage condition : Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Uniprot ID : P04156
Alternative Name : PrP, ASCR, PrP27-30, PrP33-35C, CD230
Molecular Characterization: PRNP(Lys23-Gly229) hFc(Glu99-Ala330)
Molecular weight: The protein has a predicted molecular mass of 48.8 kDa after removal of the signal peptide. The apparent molecular mass of PRNP-hFc is approximately 55-70 kDa due to glycosylation.
Description: Recombinant human PRNP protein with C-terminal human Fc tag
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants.
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