Recombinant Human Polymeric Immunoglobulin Receptor/PIgR (C-His)
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| Amount : | 50 µg |
| Content : | Lyophilized from a 0.2 um filtered solution of PBS, pH7.5 |
| AA sequence : | Recombinant Human Polymeric Immunoglobulin Receptor is produced by Human 293 Cells. The target gene encoding K19-R638 is expressed with a 8His tag at the C-terminus. |
| Alternative Name : | Polymeric Immunoglobulin Receptor; PIgR; Poly-Ig Receptor; Hepatocellular Carcinoma- Associated Protein TB6; PIGR |
Source : Human 293 Cells;
Polymeric Immunoglobulin Receptor (pIgR) is a type I transmembrane glycoprotein. pIgR is expressed by secretory epithelial cells with five Ig-like domains in the extracellular region, and transfer to the basolateral plasma membrane where it can bind larger polymers of IgA (pIgA ) and pentameric IgM. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs and separates the extracellular (known as the secretory component) from the transmembrane segment.
Polymeric Immunoglobulin Receptor (pIgR) is a type I transmembrane glycoprotein. pIgR is expressed by secretory epithelial cells with five Ig-like domains in the extracellular region, and transfer to the basolateral plasma membrane where it can bind larger polymers of IgA (pIgA ) and pentameric IgM. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs and separates the extracellular (known as the secretory component) from the transmembrane segment.
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