Recombinant Human Phospholipid Scramblase 3
Shipping Info:
For estimated delivery dates, please contact us at [email protected]
| Amount : | 25 µg |
| Purification : | Greater than 90% as determined by SDS-PAGE. |
| Content : | PLSCR3 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M urea. |
| Storage condition : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| AA sequence : | MGSSHHHHHH SSGLVPRGSH MGSMAGYLPP KGYAPSPPPP YPVTPGYPEP ALHPGPGQAP VPAQVPAPAP GFALFPSPGP VALGSAAPFL PLPGVPSGLE FLVQIDQILI HQKAERVETF LGWETCNRYE LRSGAGQPLG QAAEESNCCA RLCCGARRPL RVRLADPGDR EVLRLLRPLH CGCSCCPCGL QEMEVQAPPG TTIGHVLQTW HPFLPKFSIQ DADRQTVLRV VGPCWTCGCG TDTNFEVKTR DESRSVGRIS KQWGGLVREA LTDADDFGLQ FPLDLDVR |
| Alternative Name : | Phospholipid scramblase 3, PL scramblase 3, Ca(2+)-dependent phospholipid scramblase 3. |
Source : Escherichia Coli.
PLSCR3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 288 amino acids (1-265 a.a) and having a molecular mass of 30.9kDa.PLSCR3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Phospholipid
Scramblase 3, (PLSCR3) may mediate accelerated ATP-independent bidirectional
transbilayer migration of phospholipids upon binding calcium ions which results
in a loss of phospholipid asymmetry in the plasma membrane. PLSCR3
may play a key role in the initiation of fibrin clot formation, in the
activation of mast cells and in the recognition of apoptotic and injured cells
by the reticuloendothelial system. In addition, PLSCR3 seems to play a role in
apoptosis, through
translocation of cardiolipin from the inner to the outer mitochondrial membrane
which promotes BID recruitment and enhances tBid-induced mitochondrial damages.
Among the diseases associated with PLSCR3 are brain ischemia, and ischemia.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
|
There are currently no product reviews
|
.png "ACE2/HEK293 Stable Cell Line")
