Recombinant Human NP-1(Discontinued)
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| Amount : | 20 µg |
| Purification : | Purity: >= 98% by SDS-PAGE gel and HPLC analyses. |
| Content : | This recombinant protein is supplied in lyophilized form. |
| AA sequence : | ACYCRIPACI AGERRYGTCI YQGRLWAFCC |
| Alternative Name : | Neutrophil Peptide-1, alpha Defensin-1, HNP-1, Cryptdin |
Source:E.coli
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The Alpha-defensins, which include NP-1, NP-2 and NP-3, are distinguished from the Beta-defensins by the pairing of their three disulfide bonds. In addition to antimicrobial activity, NP-1 exhibits chemotactic activity on dendritic cells. NP-1 is expressed as the C-terminal portion of an inactive precursor protein, which also contains a 19 amino acid N-terminal signal sequence and a 45 amino acid polypeptide. NP-1 contains a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant Human NP-1 is a 3.4 kDa protein containing 30 amino acid residues.
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The Alpha-defensins, which include NP-1, NP-2 and NP-3, are distinguished from the Beta-defensins by the pairing of their three disulfide bonds. In addition to antimicrobial activity, NP-1 exhibits chemotactic activity on dendritic cells. NP-1 is expressed as the C-terminal portion of an inactive precursor protein, which also contains a 19 amino acid N-terminal signal sequence and a 45 amino acid polypeptide. NP-1 contains a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant Human NP-1 is a 3.4 kDa protein containing 30 amino acid residues.
Determined by its ability to chemoattract immature dendritic cells using a concentration of 1.0-10.0 ng/ml.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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