Recombinant Human Myelin Protein Zero-Like 1
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| Amount : | 10 µg |
| Purification : | Greater than 90% as determined by SDS-PAGE. |
| Content : | The MPZL1 solution contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 20% glycerol. |
| Storage condition : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| AA sequence : | MGSSHHHHHH SSGLVPRGSH MGSLEVYTPK EIFVANGTQG KLTCKFKSTS TTGGLTSVSW SFQPEGADTT VSFFHYSQGQ VYLGNYPPFK DRISWAGDLD KKDASINIEN MQFIHNGTYI CDVKNPPDIV VQPGHIRLYV VEKENLPV. |
| Alternative Name : | Myelin Protein Zero-Like 1, PZRa, PZR, Protein Zero-Related, PZRb, Immunoglobulin Family Transmembrane Protein, Myelin Protein Zero-Like Protein 1, MPZL1b, Protein Zero Related, PZR1b. |
Source : Escherichia Coli.
MPZL1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 148 amino acids (38-162) and having a molecular mass of 16.1kDa.MPZL1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Myelin Protein Zero-Like 1 (MPZL1) is a cell surface receptor, which is involved in signal transduction processes. MPZL1 recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. MPZL1 is a main receptor for concanavalin-A (ConA) and it is involved in cellular signaling induced by ConA, which most likely includes Src family tyrosine-protein kinases. MPZL1 Isoform 3 appears to have a dominant negative role by blocking tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, might be involved in regulation of integrin-mediated cell motility.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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