Recombinant Human Lumican
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| Amount : | 20 µg |
| Purification : | "Greater than 90.0% as determined by SDS-PAGE." |
| Content : | LUM protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Storage condition : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| AA sequence : | MGSSHHHHHH SSGLVPRGSH MGSQYYDYDF PLSIYGQSSP NCAPECNCPE SYPSAMYCDE LKLKSVPMVP PGIKYLYLRN NQIDHIDEKA FENVTDLQWL ILDHNLLENS KIKGRVFSKL KQLKKLHINH NNLTESVGPL PKSLEDLQLT HNKITKLGSF EGLVNLTFIH LQHNRLKEDA VSAAFKGLKS LEYLDLSFNQ IARLPSGLPV SLLTLYLDNN KISNIPDEYF KRFNALQYLR LSHNELADSG IPGNSFNVSS LVELDLSYNK LKNIPTVNEN LENYYLEVNQ LEKFDIKSFC KILGPLSYSK IKHLRLDGNR ISETSLPPDM YECLRVANEV TLN. |
| Alternative Name : | Lumican, LDC, Lumican Proteoglycan, Keratan Sulfate Proteoglycan Lumican, SLRR2D, KSPG Lumican. |
Source : Escherichia Coli.
LUM Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 343 amino acids (19-338a.a) and
having a molecular mass of 30.9kDa.LUM is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Lumican
also known as LUM belongs to the small leucine-rich proteoglycan (SLRP) family
which comprises decorin, biglycan, fibromodulin, keratocan, epiphycan, and
osteoglycin. Furthermore we can see that in these bifunctional molecules, the
protein moiety binds collagen fibrils and the highly charged hydrophilic
glycosaminoglycans regulate
interfibrillar spacings. Lumican is the main keratan sulfate proteoglycan of the cornea however LUM is
also distributed in interstitial
collagenous matrices throughout the body. Lumican regulates collagen
fibril organization and circumferential growth, corneal transparency,
epithelial cell migration and tissue repair. Among the diseases associated with
LUM is posterior amorphous corneal dystrophy.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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