Recombinant Human LAMTOR4
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| Amount : | 10 µg |
| Purification : | Greater than 85.0% as determined by SDS-PAGE. |
| Content : | LAMTOR4 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Storage condition : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| AA sequence : | MGSSHHHHHH SSGLVPRGSH MGSMTSALTQ GLERIPDQLG YLVLSEGAVL ASSGDLENDE QAASAISELV STACGFRLHR GMNVPFKRLS VVFGEHTLLV TVSGQRVFVV KRQNRGREPI DV. |
| Alternative Name : | Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 4, C7orf59, Late Endosomal/Lysosomal Adaptor And MAPK And MTOR Activator 4, Chromosome 7 Open Reading Frame 59, Ragulator Complex Protein LAMTOR4, UPF0539 Protein C7orf59, LAMTOR4. |
Source : Escherichia Coli.
LAMTOR4 Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 122 amino acids (1-99 a.a) and
having a molecular mass of 13.1kDa.
LAMTOR4 is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
LAMTOR4 is implicated in amino acid sensing and activation of mTORC1,
which is a signaling complex promoting cell growth in response to growth
factors, energy levels, and amino acids. LAMTOR4 is activated by amino acids via
a mechanism which involves the lysosomal V-ATPase, the Ragulator functions as a
guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator
and Rag GTPases both function as a scaffold recruiting mTORC1 to lysosomes
where it is sequentially activated.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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