Recombinant Human Isocitrate Dehydrogenase 1/IDH1 (C-8His)

Product code: 32-8688

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Available Pack Size(s)

  •   10 µg

  •  50 µg

  • $413.00 

  • $679.00 

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Shipping Info:

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Amount : 50 µg
Content : Supplied as a 0.2 µm filtered solution of 50mM Tris, 200mM NaCl, 10% glycerol, pH8.0.
Storage condition : Store at -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
AA sequence : MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKLSLEHHHHHHHH
Gene : IDH1
Gene ID : 3417
Uniprot ID : O75874
Source: E.coli.
MW :48.1kD.
Recombinant Human Isocitrate Dehydrogenase is produced by our E.coli expression system and the target gene encoding Met1-Leu414 is expressed with a 8His tag at the C-terminus. Isocitrate Dehydrogenase [NADP] Cytoplasmic (IDH1) belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 exists as a homodimer, binding one magnesium or manganese ion per subunit. Mutations of IDH1 have been shown to cause metaphyseal chondromatosis with aciduria and are involved in the development of glioma IDH plays a role in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the a-hydroxylation of phytanic acid.

Endotoxin : Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Peroxisome
Post transnational modification: Acetylation at Lys-374 dramatically reduces catalytic activity.
BioGrid: 109643. 62 interactions.
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