Recombinant Human IL-36RA(Discontinued)
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| Amount : | 25 µg |
| Purification : | Purity:>= 98% by SDS-PAGE gel and HPLC analyses. |
| Content : | This recombinant protein is supplied in lyophilized form. |
| AA sequence : | VLSGALCFRM KDSALKVLYL HNNQLLAGGL HAGKVIKGEE ISVVPNRWLD ASLSPVILGV QGGSQCLSCG VGQEPTLTLE PVNIMELYLG AKESKSFTFY RRDMGLTSSF ESAAYPGWFL CTVPEADQPV RLTQLPENGG WNAPITDFYF QQCD |
| Alternative Name : | Interleukin-36RA, FIL1 delta, IL-1F5, IL-1HY1, IL-1L1, IL-1RP3, IL-1ra Homolog 1, IL-1 delta |
Source:E.coliThe IL-1 family is comprised of 11 structurally related ligands, including the recently re-named IL-36RA (IL-1F5), IL-36Alpha (IL-1F6), IL-36Beta (IL-1F8), and IL-36Gamma (IL-1F9). The interaction of IL-36 ligands with the IL-1Rrp2 receptor (IL-1R6) can induce various activities, including dendritic cell maturation and activation. IL-36RA can antagonize the NF-kB signaling induced by either IL-36Alpha , Beta or Gamma by binding to the IL-1Rrp2 receptor in a manner that prevents the initiation of functional signaling. Recombinant Human IL-36RA is an E. coli-derived 17 kDa protein containing 154 amino acid residues.
Measured by its ability to inhibit secretion of IL-8 by A431 cells in the presence of IL-36Gamma.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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