Recombinant Human IL-36 Alpha (IL-1F6)(Discontinued)
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| Amount : | 10 µg |
| Purification : | Purity:>= 98% by SDS-PAGE gel and HPLC analyses. |
| Content : | This recombinant protein is supplied in lyophilized form. |
| AA sequence : | MKIDTPQQGS IQDINHRVWV LQDQTLIAVP RKDRMSPVTI ALISCRHVET LEKDRGNPIY LGLNGLNLCL MCAKVGDQPT LQLKEKDIMD LYNQPEPVKS FLFYHSQSGR NSTFESVAFP GWFIAVSSEG GCPLILTQEL GKANTTDFGL TMLF |
| Alternative Name : | Interleukin-36 Alpha , IL36A, Interleukin-1 family member 6 (IL-1F6), FIL1Epsilon (FIL1E), Interleukin-1Epsilon (IL1E) |
Source:E.coliThe IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36Alpha (IL-1F6), Beta (IL-1F8), and Gamma (IL-1F9). IL-36Alpha is highly expressed in psoriatic plaques, as are IL-36Beta and IL-36Gamma, and is the only IL-1 family member found to be expressed by T cells, as well as monocytes and B cells. Primarily found in skin and lymphoid tissues, IL-36Alpha is also found to a lesser extent in tissues of the fetal brain, trachea, stomach, and intestine. IL-36Alpha signals through a combination of the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells, and the widely expressed IL-RAcP (IL-1 receptor accessory protein). IL-36Alpha also functions as an agonist of NF-kappaB and MAPK pathways, and induces the production of proinflammatory cytokines and chemokines, including IL-6, IL-8, BD-2, and BD-3. Recombinant human IL-36Alpha is a 17.2 kDa protein containing 154 amino acid residues.
Measured by its ability to induce IL-8 secretion by A431 human epidermoid carcinoma cells.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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