Recombinant Human IL-16 (121 a.a.)(Discontinued)

Product code: 32-20376

Reactivity : Mouse

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Amount : 10 µg
Purification : Purity: >= 98% by SDS-PAGE gel and HPLC analyses.
Content : This recombinant protein is supplied in lyophilized form.  
AA sequence : SAASASAASD VSVESTAEAT VCTVTLEKMS AGLGFSLEGG KGSLHGDKPL TINRIFKGAA SEQSETVQPG DEILQLGGTA MQGLTRFEAW NIIKALPDGP VTIVIRRKSL QSKETTAAGD S
Alternative Name : LCF (Lymphocyte Chemoattractant Factor)
Source:E.coli
IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells, CD4+ monocytes, and eosinophils.  Analysis by gel filtration suggests that, under physiological conditions, hIL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer.  However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity.  IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4 + T cells.  Human and murine IL-16 show significant cross-species reactivity.  Recombinant Human IL-16 is a 12.4 kDa protein consisting of 121 amino acid residues.

Determined by its ability to chemoattract human CD4+ T lymphocytes using a concentration range of 50.0-100.0 ng/ml.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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