Recombinant Human IGF-BP6(Discontinued)

Product code: 32-20660

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Amount : 20 µg
Purification : Purity:>= 95% by SDS-PAGE gel and HPLC analyses.
Content : This recombinant protein is supplied in lyophilized form.  
AA sequence : RCPGCGQGVQ AGCPGGCVEE EDGGSPAEGC AEAEGCLRRE GQECGVYTPN CAPGLQCHPP KDDEAPLRAL LLGRGRCLPA RAPAVAEENP KESKPQAGTA RPQDVNRRDQ QRNPGTSTTP SQPNSAGVQD TEMGPCRRHL DSVLQQLQTE VYRGAQTLYV PNCDHRGFYR KRQCRSSQGQ RRGPCWCVDR MGKSLPGSPD GNGSSSCPTG SSG
Alternative Name : Insulin-like Growth Factor-Binding Protein 6, IBP-6
Source:(BTI-Tn-5B1-4) Hi-5 Insect cells
IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids.  IGF-BP6, which specifically inhibits IGF-II actions, is produced by bone cells and is the major IGF-BP present in cerebrospinal fluid.  IGF-BP6 has been shown to inhibit IGF-II-dependent cancers such as neuroblastoma, colon cancer and rhabdomyosarcoma.  Recombinant Human IGF-BP6 has a calculated mass of 22.3 kDa and consists of 213 amino acid residues, including the IGF-BP domain and thyroglobulin type-I domain.  Recombinant Human IGF-BP6 migrates at an apparent molecular weight of approximately 23.0-30.0 kDa by SDS-PAGE analysis under non-reducing conditions.

Determined by its ability to inhibit IGF-II induced proliferation of human MCF-7 cells. The expected ED50for this effect is 0.1 – 0.4 µg/ml.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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