Recombinant Human IFN-Beta (Discontinued)
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| Amount : | 20 µg |
| Purification : | Purity:>= 95% by SDS-PAGE gel and HPLC analyses. |
| Content : | This recombinant protein is supplied in lyophilized form. |
| AA sequence : | MSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY CLKDRMNFDI PEEIKQLQQF QKEDAALTIY EMLQNIFAIF RQDSSSTGWN ETIVENLLAN VYHQINHLKT VLEEKLEKED FTRGKLMSSL HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI LRNFYFINRL TGYLRN |
| Alternative Name : | Fibroblast Interferon, IFNB1, Type I Interferon |
Source:CHO cells
Proteins of this family play an important role in inducing non-specific resistance against a broad range of viral infections. They also affect cell proliferation and modulate immune responses. Produced by peripheral blood leukocytes and lymphoblastoid cells, IFN-Alpha is an acid-stable molecule that signals through IFN-Alpha /Beta R, which is also used by IFN-Beta . Both IFNs have similar anti-viral activity and regulate expression of MHC class I antigens. IFN-Alpha contains four highly conserved cysteine residues that form two disulfide bonds, one of which is necessary for biological activity. The Recombinant Human IFN-Beta is a 20.0 kDa protein containing 166 amino acid residues. Due to glycosylation, IFN-Beta has an approximate MW of 22.3 kDa based on SDS-PAGE gel and Mass Spectrometry.
Proteins of this family play an important role in inducing non-specific resistance against a broad range of viral infections. They also affect cell proliferation and modulate immune responses. Produced by peripheral blood leukocytes and lymphoblastoid cells, IFN-Alpha is an acid-stable molecule that signals through IFN-Alpha /Beta R, which is also used by IFN-Beta . Both IFNs have similar anti-viral activity and regulate expression of MHC class I antigens. IFN-Alpha contains four highly conserved cysteine residues that form two disulfide bonds, one of which is necessary for biological activity. The Recombinant Human IFN-Beta is a 20.0 kDa protein containing 166 amino acid residues. Due to glycosylation, IFN-Beta has an approximate MW of 22.3 kDa based on SDS-PAGE gel and Mass Spectrometry.
Assay #1:Determined by its ability to induce STAT1/STAT2 activation in Human COLO 205 ISRE LUC reporter cells.Assay #2:Determined by a cytotoxicity assay using human TF-1 cells. The expected ED50 is <=0.1 ng/ml, corresponding to a specific activity of>= 1 x 107 units/mg.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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