Recombinant Human GRPR Protein, hFc Tag

Product code: 32-18205

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Available Pack Size(s)

  •   100 µg

  •   50 µg

  • $574.00 

  • $474.00 

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Amount : 50 µg
Content : Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.
Storage condition : Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Uniprot ID : P30550
Alternative Name : BB2; BB2R; BRS2
Molecular Characterization: GRPR(Met1-Gly38) hFc(Glu99-Ala330)
Molecular weight: The protein has a predicted molecular mass of 30.4 kDa after removal of the signal peptide. The apparent molecular mass of GRPR-hFc is approximately 35-55 kDa due to glycosylation.
Description: Recombinant Human GRPR Protein with C-terminal human Fc tag
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
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